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Phenytoin (Dilantin) Correction for Albumin/Renal Failure

Código: 333 · phenytoin_dilantin_correction_albumin_renal_failure

Corrects serum phenytoin level for renal failure and/or hypoalbuminemia.

Formula

Referencias

Original/Primary Reference

  1. Martin E, Tozer TN, Sheiner LB, Riegelman S. The clinical pharmacokinetics of phenytoin. J Pharmacokinet Biopharm. 1977 Dec;5(6):579-96. ↗
  2. Sheiner LB, Tozer TN. Clinical pharmacokinetics: the use of plasma concentrations of drugs. In: Melmon KL, Morelli HF, editors. Clinical Pharmacology: Basic Principles in Therapeutics. New York: Macmillan; 1978. p.71-109. ↗
  3. Winter MG, Tozer TN. Chapter 20. Phenytoin. In: Burton ME, Shaw LM, Schentag JJ, Evans WE. Applied pharmacokinetics: principles of therapeutic drug monitoring. 4th ed. Baltimore, MD: Lippincott Williams & Wilkins, ©2006. ↗

Other References

  1. Vajda FJ, Eadie MJ. The clinical pharmacology of traditional antiepileptic drugs. Epileptic Disord. 2014;16:395-408. ↗
  2. Hong JM, Choi YC, Kim WJ. Differences between the Measured and Calculated Free Serum Phenytoin Concentrations in Epileptic Patients. Yonsei Medical Journal. 2009;50(4):517-520. ↗
  3. Liponi DF, Winter ME, Tozer TN. Renal function and therapeutic concentrations of phenytoin. Neurology 1984;34:395-7. ↗
  4. Kane SP, Bress AP, Tesoro EP. Characterization of unbound phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation. Ann Pharmacother. 2013;47(5):628-36. ↗
  5. Anderson GD, Pak C, Doane KW, et al. Revised Winter-Tozer equation for normalized phenytoin concentrations in trauma and elderly patients with hypoalbuminemia. Ann Pharmacother. 1997;31(3):279-84. ↗
  6. Cheng W, Kiang TKL, Bring P, Ensom MHH. Predictive Performance of the Winter–Tozer and Derivative Equations for Estimating Free Phenytoin Concentration. The Canadian Journal of Hospital Pharmacy. 2016;69(4):269-279. ↗
  7. Soriano VV, Tesoro EP, Kane SP. Characterization of Free Phenytoin Concentrations in End-Stage Renal Disease Using the Winter-Tozer Equation. Ann Pharmacother. 2017;:1060028017707541. ↗
  8. Kiang TK, Ensom MH. A Comprehensive Review on the Predictive Performance of the Sheiner-Tozer and Derivative Equations for the Correction of Phenytoin Concentrations. Ann Pharmacother. 2016;50(4):311-25. ↗